Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes
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چکیده
منابع مشابه
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.
The enteric nervous system (ENS) is composed of neurons and glial cells, organized as interconnected ganglia within the gut wall, which controls peristalsis of the gut wall and secretions from its glands. The Ret receptor tyrosine kinase is expressed throughout enteric neurogenesis and is required for normal ENS development; humans with mutations in the RET locus have Hirschsprung disease (HSCR...
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The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ion channels, including chloride, calcium, potassium and sodium channels were already expressed by ENCCs at E11.5. There was an increase i...
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†Biozentrum and Swiss Institute of Bioinformatics, 4056 Basel; Switzerland; ‡Genomics Platform, National Center of Competence in Research Frontiers in Genetics, Université de Genève/CMU, 1211 Geneva 4, Switzerland; and §Group d’Etude de la Reproduction chez le Male-Institut National de la Santé et de la Recherche Médicale U. 435, Université de Rennes I, Campus de Beaulieu, 35042 Rennes cedex, B...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0602152103